The Schistosomiasis Resource Center at the Biomedical Research Institute (BRI) is a unique schistosomiasis research supply laboratory funded by the NIAID at the National Institutes of Health.

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Angeli A, Ferraroni M, Da’dara AA, et al. Structural Insights into Schistosoma mansoni Carbonic Anhydrase (SmCA) Inhibition by Selenoureido-Substituted Benzenesulfonamides. J Med Chem. 2021;64(14):10418-10428. doi:10.1021/ACS.JMEDCHEM.1C00840

Buchter V, Schneeberger PHH, Keiser J. Validation of a human-serum-based in vitro growth method for drug screening on juvenile development stages of Schistosoma mansoni. PLoS Negl Trop Dis. 2021;15(3):e0009313. doi:10.1371/JOURNAL.PNTD.0009313

Civitello DJ, Baker LH, Maduraiveeran S, Hartman RB. Resource fluctuations inhibit the reproduction and virulence of the human parasite Schistosoma mansoni in its snail intermediate host. Proc R Soc B. 2020;287(1919). doi:10.1098/RSPB.2019.2446

Coelho FS, Rodpai R, Miller A, et al. Diminished adherence of Biomphalaria glabrata embryonic cell line to sporocysts of Schistosoma mansoni following programmed knockout of the allograft inflammatory factor. Parasites Vectors 2020 131. 2020;13(1):1-12. doi:10.1186/S13071-020-04384-9

Cortes-Selva D, Gibbs L, Maschek JA, et al. Metabolic reprogramming of the myeloid lineage by Schistosoma mansoni infection persists independently of antigen exposure. PLoS Pathog. 2021;17(1). doi:10.1371/JOURNAL.PPAT.1009198. PMID: 33417618

Cortés-Selva D, Gibbs L, Ready A, et al. Maternal schistosomiasis impairs offspring Interleukin-4 production and B cell expansion. PLOS Pathog. 2021;17(2):e1009260. doi:10.1371/JOURNAL.PPAT.1009260

Craven HM, Bonsignore R, Lenis V, et al. Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni. PLoS Negl Trop Dis. 2021;15(2):e0008770. doi:10.1371/JOURNAL.PNTD.0008770

Crego-Vicente B, Fernández-Soto P, Febrer-Sendra B, et al. Application of a Genus-Specific LAMP Assay for Schistosome Species to Detect Schistosoma haematobium x Schistosoma bovis Hybrids. J Clin Med. 2021;10(6):1308. doi:10.3390/JCM10061308. PMID: 33810080

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Fogarty CE, Zhao M, Mcmanus DP, Duke MG, Cummins SF, Wang T. Comparative study of excretory-secretory proteins released by Schistosoma mansoni-resistant, susceptible and naïve Biomphalaria glabrataParasit Vectors. 2019;12(1). doi:10.1186/s13071-019-3708-0

Frahm S, Anisuzzaman A, Prodjinotho UF, Vejzagić N, Verschoor A, Costa CP da. A novel cell-free method to culture Schistosoma mansoni from cercariae to juvenile worm stages for in vitro drug testing. PLoS Negl Trop Dis. 2019;13(1):e0006590. doi:10.1371/JOURNAL.PNTD.0006590

Gao J, Yang N, Lewis F, et al. A rotifer-derived paralytic compound prevents transmission of schistosomiasis to a mammalian host. PLoS Biol. 2019;17(10). doi:10.1371/JOURNAL.PBIO.3000485. PMID: 31622335

Hagerty JR, Kim HC, Jolly ER. Multiomic analysis of Schistosoma mansoni reveals unique expression profiles in cercarial heads and tails. Commun Biol. 2021;4(1):1-11. doi:10.1038/s42003-021-02366-w

Hambrook J, Gharamah A, Pila E, Hussein S, Hanington P. Biomphalaria glabrata Granulin Increases Resistance to Schistosoma mansoni Infection in Several Biomphalaria Species and Induces the Production of Reactive Oxygen Species by Haemocytes. Genes (Basel). 2019;11(1). doi:10.3390/GENES11010038. PMID: 31905675

Hassan AS, Zelt NH, Perera DJ, Ndao M, Ward BJ. Vaccination against the digestive enzyme Cathepsin B using a YS1646 Salmonella enterica Typhimurium vector provides almost complete protection against Schistosoma mansoni challenge in a mouse model. PLoS Negl Trop Dis. 2019;13(12):e0007490.

Ittiprasert W, Mann VH, Karinshak SE, et al. Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni. Elife. 2019;8. doi:10.7554/ELIFE.41337

Jones DK, Davila DD, Nguyen KH, Rohr JR. Effect of Agrochemical Exposure on Schistosoma mansoni Cercariae Survival and Activity. Environ Toxicol Chem. 2020;39(7):1421-1428. doi:10.1002/ETC.4732

Kumar R, Mickael C, Kassa B, et al. Th2 CD4+ T Cells Are Necessary and Sufficient for Schistosoma‐Pulmonary Hypertension. J Am Heart Assoc. 2019;8(15). doi:10.1161/JAHA.119.013111

Lam HYP, Liang T-R, Peng S-Y. Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo. PLoS Negl Trop Dis. 2021;15(6):e0009554. doi:10.1371/JOURNAL.PNTD.0009554

Lee J, Chong T, Newmark PA. The esophageal gland mediates host immune evasion by the human parasite Schistosoma mansoni. Proc Natl Acad Sci. 2020;117(32):19299-19309. doi:10.1073/PNAS.2006553117. PMID: 32737161

Li H, Hambrook JR, Pila EA, et al. Coordination of humoral immune factors dictates compatibility between Schistosoma mansoni and Biomphalaria glabrata. Elife. 2020;9. doi:10.7554/ELIFE.51708

Loc L, Mbanefo E, Khludenev G, Lamanna O, Banskota N, Hsieh M. Schistosoma haematobium cercarial infection alters subsequent systemic immune responses to eggs but has minimal impact on immune responses to egg injection of the bladder. Parasite Immunol. 2019;41(1). doi:10.1111/PIM.12602. PMID: 30417508.

Mayer JU, Brown SL, MacDonald AS, Milling SW. Defined Intestinal Regions Are Drained by Specific Lymph Nodes That Mount Distinct Th1 and Th2 Responses Against Schistosoma mansoni Eggs. Front Immunol. 2020;0:2745. doi:10.3389/FIMMU.2020.592325

Mekonnen G, Tedla B, Pickering D, et al. Schistosoma haematobium Extracellular Vesicle Proteins Confer Protection in a Heterologous Model of Schistosomiasis. Vaccines. 2020;8(3):1-20. doi:10.3390/VACCINES8030416. PMID: 32722279

Melkus MW, Le L, Siddiqui AJ, et al. Elucidation of Cellular Responses in Non-human Primates with Chronic Schistosomiasis Followed by Praziquantel Treatment. Front Cell Infect Microbiol. 2020;10:57. doi:10.3389/FCIMB.2020.00057. PMID: 32154190

Mickael C, Kumar R, Hernandez-Saavedra D, et al. IL-6Ra in Smooth Muscle Cells Protects against Schistosoma- and Hypoxia-induced Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2019;61(1):123-126. doi:10.1165/RCMB.2018-0277LE. PMID: 31259624

Mickael CS, Graham BB. The Role of Type 2 Inflammation in Schistosoma-Induced Pulmonary Hypertension. Front Immunol. 2019;10(JAN):27. doi:10.3389/FIMMU.2019.00027. PMID: 30733718

Molehin AJ, Gray SA, Turner C, et al. Process Development of Sj-p80: A Low-Cost Transmission-Blocking Veterinary Vaccine for Asiatic Schistosomiasis. Front Immunol. 2021;0:3928. doi:10.3389/FIMMU.2020.578715

Nacif-Pimenta R, da Silva Orfanó A, Mosley IA, et al. Differential responses of epithelial cells from urinary and biliary tract to eggs of Schistosoma haematobium and S. mansoni. Sci Reports 2019 91. 2019;9(1):1-15. doi:10.1038/s41598-019-46917-y

Nguyen KH, Boersch-Supan PH, Hartman RB, et al. Interventions can shift the thermal optimum for parasitic disease transmission. Proc Natl Acad Sci. 2021;118(11). doi:10.1073/PNAS.2017537118. PMID: 33836584

Park S, Gunaratne G, Chulkov E, et al. The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel. J Biol Chem. 2019;294(49):18873-18880. doi:10.1074/JBC.AC119.011093. PMID: 31653697

Pearson MS, Tedla BA, Becker L, et al. Immunomics-Guided Antigen Discovery for Praziquantel-Induced Vaccination in Urogenital Human Schistosomiasis. Front Immunol. 2021;0:1653. doi:10.3389/FIMMU.2021.663041

Pennance T, Archer J, Lugli EB, et al. Development of a Molecular Snail Xenomonitoring Assay to Detect Schistosoma haematobium and Schistosoma bovis Infections in their Bulinus Snail Hosts. Molecules. 2020;25(17):4011. doi:10.3390/MOLECULES25174011. PMID: 32887445

Perera DJ, Hassan AS, Jia Y, et al. Adjuvanted Schistosoma mansoni-Cathepsin B With Sulfated Lactosyl Archaeol Archaeosomes or AddaVaxTM Provides Protection in a Pre-Clinical Schistosomiasis Model. Front Immunol. 2020;0:2990. doi:10.3389/FIMMU.2020.605288

Shiels J, Cwiklinski K, Alvarado R, et al. Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs). PLoS Negl Trop Dis. 2020;14(7):e0008470. doi:10.1371/JOURNAL.PNTD.0008470

Skinner D, Popratiloff A, Alrefaei Y, Mann V, Rinaldi G, Brindley P. Functional analysis of vasa/PL10-like genes in the ovary of Schistosoma mansoniMol Biochem Parasitol. 2020;236. doi:10.1016/J.MOLBIOPARA.2020.111259. PMID: 31958469

Stroehlein AJ, Korhonen PK, Chong TM, et al. High-quality Schistosoma haematobium genome achieved by single-molecule and long-range sequencing. Gigascience. 2019;8(9):1-12. doi:10.1093/GIGASCIENCE/GIZ108

Tedla B, Pickering D, Becker L, Loukas A, Pearson M. Vaccination with Schistosoma mansoni Cholinesterases Reduces the Parasite Burden and Egg Viability in a Mouse Model of Schistosomiasis. Vaccines. 2020;8(2). doi:10.3390/VACCINES8020162. PMID: 32260125

Wang J, Paz C, Padalino G, et al. Large-scale RNAi screening uncovers therapeutic targets in the parasite Schistosoma mansoni. Science. 2020;369(6511):1649-1653. doi:10.1126/SCIENCE.ABB7699. PMID: 32973031

Weber CJ, Hargan-Calvopiña J, Graef KM, Manner CK, Dent J. WIPO A Platform for Product-Centered Cross-Sector Partnerships for the Elimination of Schistosomiasis. Trop Med Infect Dis. 2019;4(1):11. doi:10.3390/TROPICALMED4010011

Yombo D, Mentink-Kane M, Wilson M, Wynn T, Madala S. Heat shock protein 70 is a positive regulator of airway inflammation and goblet cell hyperplasia in a mouse model of allergic airway inflammation. J Biol Chem. 2019;294(41):15082-15094. doi:10.1074/JBC.RA119.009145. PMID: 31431507

You H, Mayer J, Johnston R, et al. CRISPR/Cas9-mediated genome editing of Schistosoma mansoni acetylcholinesterase. FASEB J. 2021;35(1). doi:10.1096/FJ.202001745RR. PMID: 33337558

Young ND, Kinkar L, Stroehlein AJ, et al. Mitochondrial genome of Bulinus truncatus (Gastropoda: Lymnaeoidea): Implications for snail systematics and schistosome epidemiology. Curr Res Parasitol Vector-Borne Dis. 2021;1:100017. doi:10.1016/J.CRPVBD.2021.100017

Kifle, D. W., Chaiyadet, S., Waardenberg, A. J., Wise, I., Cooper, M., Becker, L., Doolan, D. L., Laha, T., Sotillo, J., Pearson, M. S., & Loukas, A. (2020). Uptake of Schistosoma mansoni extracellular vesicles by human endothelial and monocytic cell lines and impact on vascular endothelial cell gene expression. International Journal for Parasitology50(9), 685–696.

Park, S.-K., Friedrich, L., Yahya, N. A., Rohr, C. M., Chulkov, E. G., Maillard, D., Rippmann, F., Spangenberg, T., & Marchant, J. S. (2021). Mechanism of praziquantel action at a parasitic flatworm ion channel. Science Translational Medicine13(625).