The Symposium for International Research and Innovation in Schistosomiasis (SIRIS) February 2016

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Stay tuned for the next BRI SIRIS conference in 2018

Symposium for International Research and Innovations in Schistosomiasis
February 3 – 4, 2016
George Washington University
Washington, DC

Michael Hsieh, Biomedical Research Institute
Jeffrey Bethony, George Washington University
Jutta Reinhard-Rupp, Merck KGaA, Darmstadt, Germany



Wednesday, February 3, 2016


7:30 AM

Symposium Registration and Morning Coffee

9:00 AM

Chairperson’s Opening Remarks and Announcement of Trainee AwardsMichael Hsieh, MD, PhD, Biomedical Research Institute

9:15 AM

Session:Understanding Old and Potential Therapeutics for SchistosomiasisModerator: Clive Shiff9:15-9:55 Key Note Address:Phil LoVerde, PhD, University of Texas Health Science Center San AntonioSchistosoma mansoni: Genetic basis of drug resistance, drug mode of action and drug design”9:55-10:15 Winka M. Le Clec’h, “Independent origins of alleles conferring oxamniquine resistance in Brazilian schistosome parasites”10:15-10:35 Tony Walker, “Spatiotemporal Mapping of Protein Kinase activities in Schistosoma mansoni”

10:35-10:55 Conor Caffrey, ““Shake, rattle and roll:” learning how the schistosome responds to drugs”

10:55 AM

Coffee Break, Posters & Exhibits

11:15 AM

Session:Mass Drug Administration: the Road to Elimination?Moderator: Jutta Reinhard-Rupp11:15-11:35 Professor Alan Fenwick, Schistosomiasis Control Initiative, “Progress towards the elimination of schistosomiasis – 2020 or 2030?”11:35-11:55 W. Evan Secor, PhD, Centers for Disease Control and Prevention, “Impact of mass drug administration (MDA) over 5 years in villages in western Kenya with moderate or high prevalence Schistosoma mansoni infections”11:55-12:15 Daniel Colley, PhD, University of Georgia, “Annual Mass Drug Administration Often Does Not Lead to Uniform Decreases in Prevalence or Intensity of Schistosomiasis”

12:15 PM

Lunch Break, Posters & Exhibits

1:40 PM

Session:Parasite BiologyModerator: Emmitt Jolly1:40-2:00 David Rollinson, PhD, Natural History Museum London, “Snails and Schistosomiasis2:00-2:20 A. Da’Dara, “Schistosomes and Hemostasis”2:20-2:40 Jayhun Lee, “Under the skin: Exploring the developmental transition underlining the parasite cloaking of Schistosoma”2:40-3:00 Mathilde Knight, PhD, “Epigenetic Modulation, Stress, and Variation in Susceptibility of the Snail, Biomphalaria glabrata, to Schistosoma mansoni Infection”

3:00 PM

Coffee Break, Posters & Exhibits

3:20 PM

Session:Vaccines and Possible Vaccine Targets for SchistosomiasisModerator: Jeff Bethony3:20-3:40 Adebayo Molehin, “Sm-p80 Vaccine Confers Cross-Species Protection Against Schistosoma japonicum Infection in Mice”3:40-4:00 Harini Iyer, “Transcriptomic Analysis Reveals Molecular Similarity Between the Male Germline of Parasitic and Free-Living Flatworms”4:00-4:20 James Collins, “Somatic Stem Cells Drive Regeneration of the Schistosome Tegument”4:20-4:40 Mark Pearson, “Extracellular Vesicles Secreted by Schistosoma mansoni Contain Protein Vaccine Candidates”4:40-5:00 Alex Loukas, “Protein Microarrays for the Discovery of Schistosome Vaccine Antigens”

5:00 PM

Session:Manipulating the Schistos(ome)Moderator: Stephen Davies5:00-5:20 Speaker:Professor Paul Brindley, George Washington University, “HIV-1 Integrates Widely Throughout the Genome of the Human Blood Fluke Schistosoma mansoni”5:20-5:40 Emmitt Jolly, “The Heat Shock Pathway, a Potential Molecular Regulator of Schistosome Host Invasion?”

5:40 PM

First Night Reception, Posters & Exhibits



Thursday, February 4, 2016


7:30 AM

Roundtable Mentors for Trainees and Morning Coffee – Jutta Reinhard-Rupp and Michael Hsieh

8:15 AM

Chairperson’s Remarks and Announcement of Trainee AwardsMichael Hsieh, MD, PhD, Biomedical Research Institute

8:25 AM

Govert van Damm, “Diagnostics of schistosomiasis by antigen-detection (CAA and CCA): the quest for a single worm”

8:50 AM

Session:Defining Schistos(omics)Moderator: Paul Brindley8:50-9:10 Frederic Chevalier, “Population “exomics” of schistosoma mansoni”9:10-9:30 Winka M. Le Clec’h, “Genetic Analysis of Transmission-Related Traits in Schistosoma mansoni”9:30-9:50 Michael Hsieh, “Computational Deconvolution of Gene Expression by Individual Host Cellular Subsets from Microarray Analyses of Complex, Parasite-Infected Whole Tissues”9:50-10:10 Pheabian Akinwale, “Schistosoma haematobium Transmission in Nigeria: a Molecular Approach”

10:10 AM

Coffee Break, Posters & Exhibits

10:30 AM

Session:Host Pathology of SchistosomiasisModerator: Margaret Mentink-Kane10:30-10:50 Jutta Reinhard-Rupp, “Female Genital Schistosomiasis (FGS), Will It Remain the Forgotten Gynaecological Disease of the Future?”10:50-11:10 Professor Stephen Davies, USUHS, “Immune System Interactions in Schistosome Development”11:10-11:30 Keke Fairfax, “Effects of Maternal S. mansoni Infection on Offspring’s Immune Response to Tetanus Diptheria”11:30-11:50 Ellen Fox, “Induction of Type 2 Immune Responses by Cathepsin B1, an S. mansoni Cysteine Protease”11:50-12:10 Martina Laidemitt, “Biotic Diversity and Schistosomiasis Transmission: Diverse and Abundant Trematode Species Contest the Snail Environments Schistosomes Depend on for Transmission”

12:10-12:30 Thiago Almeida Pereira, “Cross-Talk Between Hedgehog and IL-13 Pathways Orchestrate Schistosomiasis Mansoni Fibrosis”

12:30 PM

Chairperson’s Closing RemarksMichael Hsieh, MD, PhD, Biomedical Research Institute

12:40 PM

Close of Symposium