The Hsieh Lab Mission
Our laboratory is interested in how epithelial organs respond to injury. The bladder is our model organ, and we focus on injuries induced during infections by microbes such as uropathogenic E. coli and Schistosoma haematobium, and chemical exposures to nitrosamines and ifosfamide. These models enable us to study host-microbe interactions during bladder infection and bladder carcinogenesis. Through our research, we seek to better understand inflammation and harness its potential for human benefit.
Besides studying the basic biology of bladder inflammation and infection, we are also collaborating with the Sheik Zayed Institute for Pediatric Surgical Innovation and the CHARM lab at Stanford to develop better diagnostic and surgical technology for children with conditions predisposing them to urinary tract infections.
Our overarching hypothesis regarding urogenital schistosomiasis is that Schistosoma haematobium eggs induce tissue-specific immune responses that result in compromised host defense and… More >>
We are examining the role of the urine microbiome in health and disease, as well as the in vivo mechanisms by which bacteria resist antibiotics and the host immune system. More >>