The Hsieh Lab Mission
Our laboratory is interested in how inflammation protects against pathogens and other noxious stimuli and yet can paradoxically harm the host through secondary effects such as carcinogenesis. The genitourinary tract is our model system. We are examining anti-pathogenic inflammation induced by bacteria such as uropathogenic E. coli. Chronic inflammation-mediated carcinogenesis is being studied using models of nitrosamine and Schistosoma haematobium exposure. Through our research, we seek to better understand inflammation and harness its potential for human benefit.
Besides studying the basic biology of genitourinary inflammation and infection, we are also collaborating with the Sheik Zayed Institute for Pediatric Surgical Innovation and the CHARM lab at Stanford to develop better diagnostic and surgical technology for children with conditions predisposing them to urinary tract infections.
Our overarching hypothesis regarding urogenital schistosomiasis is that Schistosoma haematobium eggs induce tissue-specific immune responses that result in compromised host defense and… More >>
We are examining the role of the urine microbiome in health and disease, as well as the in vivo mechanisms by which bacteria resist antibiotics and the host immune system. More >>